Motif ID: STAT5{A,B}.p2

Z-value: 1.458


Transcription factors associated with STAT5{A,B}.p2:

Gene SymbolEntrez IDGene Name
STAT5A 6776 signal transducer and activator of transcription 5A
STAT5B 6777 signal transducer and activator of transcription 5B

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
STAT5Bchr17_-_37681917-0.665.2e-03Click!
STAT5Achr17_+_37693090-0.591.7e-02Click!


Activity profile for motif STAT5{A,B}.p2.

activity profile for motif STAT5{A,B}.p2


Sorted Z-values histogram for motif STAT5{A,B}.p2

Sorted Z-values for motif STAT5{A,B}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT5{A,B}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_39860398 3.758 NM_001012320
NM_018443
ZNF302

zinc finger protein 302

chr19_-_39859997 3.223


chr5_+_145297490 2.626 SH3RF2
SH3 domain containing ring finger 2
chr19_+_49180171 2.589 NM_003445
NM_198089
ZNF155

zinc finger protein 155

chr19_+_49248003 2.199 NM_013361
ZNF223
zinc finger protein 223
chr19_+_61798434 1.992 NM_021216
ZNF71
zinc finger protein 71
chr19_+_42099073 1.923 NM_198539
ZNF568
zinc finger protein 568
chr19_-_41849558 1.874 NM_153257
ZNF461
zinc finger protein 461
chr4_+_86615275 1.764 NM_001025616
ARHGAP24
Rho GTPase activating protein 24
chr19_-_42098758 1.707 NM_001171979
ZNF829
zinc finger protein 829
chr1_+_148137778 1.421 NM_016074
BOLA1
bolA homolog 1 (E. coli)
chr19_+_58733144 1.314 NM_001079906
ZNF331
zinc finger protein 331
chr14_+_23700261 1.259 NM_006084
IRF9
interferon regulatory factor 9
chr19_+_42033106 1.207 NM_003419
ZNF345
zinc finger protein 345
chr19_+_42033564 1.099 ZNF345
zinc finger protein 345
chr6_-_46728188 1.082 NM_016593
CYP39A1
cytochrome P450, family 39, subfamily A, polypeptide 1
chr15_+_39853982 1.078 MAPKBP1
mitogen-activated protein kinase binding protein 1
chr11_-_33678861 1.060 NM_001166692
C11orf91
chromosome 11 open reading frame 91
chr7_+_89870707 1.013 CLDN12
claudin 12
chr19_-_42098919 0.975 NM_001037232
ZNF829
zinc finger protein 829
chr7_+_89870647 0.969 NM_001185072
NM_001185073
NM_012129
CLDN12


claudin 12


chr15_-_81744469 0.951 NM_001717
BNC1
basonuclin 1
chr19_+_49309350 0.943 NM_013362
ZNF225
zinc finger protein 225
chr11_-_82674546 0.943 CCDC90B
coiled-coil domain containing 90B
chr19_+_49361054 0.933 NM_001146220
NM_001032373
NM_001032374
NM_015919
NM_001032372
ZNF226




zinc finger protein 226




chr19_+_49337568 0.906 ZNF234
zinc finger protein 234
chr19_-_62680703 0.886 NM_001024596
NM_001144068
ZNF772

zinc finger protein 772

chr16_+_52295545 0.866 FTO
fat mass and obesity associated
chr1_-_199704773 0.858 NM_012396
PHLDA3
pleckstrin homology-like domain, family A, member 3
chr3_+_58459131 0.858 NM_153331
KCTD6
potassium channel tetramerisation domain containing 6
chr19_+_49337548 0.837 NM_001144824
NM_006630
ZNF234

zinc finger protein 234

chr14_-_19951417 0.832 NM_007110
TEP1
telomerase-associated protein 1
chr14_-_69953433 0.822 NM_018373
SYNJ2BP
synaptojanin 2 binding protein
chr20_+_12937616 0.814 NM_018327
SPTLC3
serine palmitoyltransferase, long chain base subunit 3
chr19_+_49198916 0.813 NM_006300
ZNF230
zinc finger protein 230
chr19_-_62912347 0.812 NM_001085384
ZNF154
zinc finger protein 154
chr19_+_49268106 0.811 NM_001037813
ZNF284
zinc finger protein 284
chr19_-_49500966 0.776 NM_004234
ZNF235
zinc finger protein 235
chr15_+_39853923 0.771 NM_001128608
NM_014994
MAPKBP1

mitogen-activated protein kinase binding protein 1

chrX_+_105932536 0.771 NM_017752
NM_198881
TBC1D8B

TBC1 domain family, member 8B (with GRAM domain)

chr8_-_99375739 0.756 NM_024759
NIPAL2
NIPA-like domain containing 2
chr12_+_12857516 0.745 NM_016355
NM_201224
DDX47

DEAD (Asp-Glu-Ala-Asp) box polypeptide 47

chr6_-_32892705 0.709 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr19_-_63205948 0.685 ZNF606
zinc finger protein 606
chr2_+_219283751 0.675 NM_014640
TTLL4
tubulin tyrosine ligase-like family, member 4
chr9_+_111582317 0.666 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr12_+_11694172 0.662 ETV6
ets variant 6
chr15_-_57452357 0.641 MYO1E
myosin IE
chr15_-_57452345 0.637 MYO1E
myosin IE
chr10_-_121345968 0.634 TIAL1
TIA1 cytotoxic granule-associated RNA binding protein-like 1
chr15_-_57452361 0.621 NM_004998
MYO1E
myosin IE
chr3_+_197951203 0.614 PAK2
p21 protein (Cdc42/Rac)-activated kinase 2
chr20_-_18425811 0.611 NM_006606
RBBP9
retinoblastoma binding protein 9
chr7_+_75928907 0.602 NM_001102594
NM_001102595
NM_020892
DTX2


deltex homolog 2 (Drosophila)


chr16_-_52295214 0.586 NM_001127897
NM_015272
RPGRIP1L

RPGRIP1-like

chr10_+_86174665 0.583 FAM190B
family with sequence similarity 190, member B
chr3_+_197951121 0.564 NM_002577
PAK2
p21 protein (Cdc42/Rac)-activated kinase 2
chr5_+_140454382 0.561 NM_018936
PCDHB2
protocadherin beta 2
chr2_+_219283928 0.556 TTLL4
tubulin tyrosine ligase-like family, member 4
chr19_+_42400908 0.555 ZNF383
zinc finger protein 383
chr3_+_132228383 0.548 NM_001146003
NM_024800
NM_145910
NEK11


NIMA (never in mitosis gene a)- related kinase 11


chr5_-_111120817 0.535 NM_004772
C5orf13
chromosome 5 open reading frame 13
chr9_-_133945064 0.532 NM_004269
CRSP8P
MED27
mediator complex subunit 27 pseudogene
mediator complex subunit 27
chr19_-_62781883 0.524 NM_017879
ZNF416
zinc finger protein 416
chr14_-_67232172 0.521 NM_016026
RDH11
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
chr19_-_62782066 0.520 ZNF416
zinc finger protein 416
chr17_-_17435631 0.519 NM_148172
PEMT
phosphatidylethanolamine N-methyltransferase
chr11_+_65024889 0.501 MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr17_-_44847215 0.495 NM_002634
PHB
prohibitin
chr1_-_219977424 0.494 NM_144728
DUSP10
dual specificity phosphatase 10
chr19_-_49309102 0.488 LOC100379224
hypothetical LOC100379224
chr2_+_95195260 0.476 ZNF2
zinc finger protein 2
chr9_-_133944877 0.471 MED27
mediator complex subunit 27
chr17_-_44847214 0.469 PHB
prohibitin
chr19_+_58715988 0.469 NM_018555
ZNF331
zinc finger protein 331
chr19_-_42777486 0.461 NM_016536
ZNF571
zinc finger protein 571
chr2_+_95194903 0.446 NM_001017396
NM_021088
ZNF2

zinc finger protein 2

chr19_-_49552638 0.435 NM_001083335
NM_013380
ZFP112

zinc finger protein 112 homolog (mouse)

chr9_-_103200697 0.423 NM_019051
MRPL50
mitochondrial ribosomal protein L50
chr19_-_63150825 0.410 NM_005773
ZNF256
zinc finger protein 256
chr1_+_93418866 0.400 CCDC18
coiled-coil domain containing 18
chr9_+_103200939 0.386 NM_003452
NM_197977
ZNF189

zinc finger protein 189

chr3_+_171422917 0.381 PRKCI
protein kinase C, iota
chr22_+_48966394 0.380 TRABD
TraB domain containing
chr9_+_129226535 0.373 ZNF79
zinc finger protein 79
chr18_+_54958095 0.372 NM_033280
SEC11C
SEC11 homolog C (S. cerevisiae)
chr10_-_62163083 0.371 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr17_+_15543771 0.370 ZNF286A
zinc finger protein 286A
chr14_+_67356248 0.365 NM_002877
NM_133509
NM_133510
RAD51L1


RAD51-like 1 (S. cerevisiae)


chr19_-_63643400 0.364 NM_003433
ZNF132
zinc finger protein 132
chr19_-_49644470 0.351 NM_014518
ZNF229
zinc finger protein 229
chr3_+_171422908 0.350 NM_002740
PRKCI
protein kinase C, iota
chr2_+_63669596 0.345 NM_005917
MDH1
malate dehydrogenase 1, NAD (soluble)
chr3_+_171422940 0.344 PRKCI
protein kinase C, iota
chr6_+_139136349 0.342 NM_015439
CCDC28A
coiled-coil domain containing 28A
chr10_+_93548162 0.336 TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr2_+_43854681 0.334 NM_001193464
NM_015522
NM_016008
DYNC2LI1


dynein, cytoplasmic 2, light intermediate chain 1


chr12_-_102413875 0.333 NM_198521
NM_001099336
C12orf42

chromosome 12 open reading frame 42

chr2_+_218843358 0.328 NM_001077399
NM_015488
PNKD

paroxysmal nonkinesigenic dyskinesia

chr9_+_129226473 0.327 NM_007135
ZNF79
zinc finger protein 79
chrX_+_46935152 0.325 UBA1
ubiquitin-like modifier activating enzyme 1
chr19_+_62638474 0.322 NM_001023561
ZNF749
zinc finger protein 749
chr1_-_33275051 0.320 AK2
adenylate kinase 2
chr10_-_33663305 0.314 NRP1
neuropilin 1
chr19_-_51058177 0.309 NM_004819
SYMPK
symplekin
chr10_+_93548048 0.306 TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr17_+_36515166 0.297 NM_001146041
KRTAP4-9
keratin associated protein 4-9
chr3_+_199161446 0.295 NM_000996
RPL35A
ribosomal protein L35a
chr19_+_62949972 0.293 NM_173632
ZNF776
zinc finger protein 776
chr17_+_5264195 0.292 RPAIN
RPA interacting protein
chr3_-_112796855 0.290 NM_024508
ZBED2
zinc finger, BED-type containing 2
chr3_-_52839727 0.290 NM_001166449
NM_002218
ITIH4

inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)

chr1_-_145608965 0.289 NM_016361
ACP6
acid phosphatase 6, lysophosphatidic
chr1_-_33275039 0.281 AK2
adenylate kinase 2
chr3_-_132228273 0.280 NM_014065
ASTE1
asteroid homolog 1 (Drosophila)
chr4_-_153820535 0.278 NM_152680
TMEM154
transmembrane protein 154
chr19_-_41672598 0.277 ZNF566
zinc finger protein 566
chr22_+_37407906 0.271 TOMM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
chr10_+_93548119 0.270 NM_025235
TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr19_+_62950001 0.269 ZNF776
zinc finger protein 776
chr14_-_81069865 0.265 SEL1L
sel-1 suppressor of lin-12-like (C. elegans)
chr22_+_37407921 0.265 TOMM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
chr15_+_40427592 0.260 NM_212465
CAPN3
calpain 3, (p94)
chr2_-_85435074 0.257 NM_017750
RETSAT
retinol saturase (all-trans-retinol 13,14-reductase)
chr1_-_33275071 0.256 NM_013411
AK2
adenylate kinase 2
chr15_-_72540518 0.255 UBL7
ubiquitin-like 7 (bone marrow stromal cell-derived)
chr1_-_33275015 0.253 AK2
adenylate kinase 2
chr1_+_246703249 0.252 NM_001005495
OR2T3
olfactory receptor, family 2, subfamily T, member 3
chr7_+_47801413 0.250 NM_025031
PKD1L1
C7orf69
polycystic kidney disease 1 like 1
chromosome 7 open reading frame 69
chr3_-_115258053 0.248 NM_020817
KIAA1407
KIAA1407
chr17_-_5263594 0.247 NUP88
nucleoporin 88kDa
chr19_+_62703113 0.247 NM_198542
ZNF773
zinc finger protein 773
chr19_-_56303434 0.246 NM_145232
CTU1
cytosolic thiouridylase subunit 1 homolog (S. pombe)
chr1_-_151788341 0.245 NM_002960
S100A3
S100 calcium binding protein A3
chr3_+_185386556 0.244 NM_018358
ABCF3
ATP-binding cassette, sub-family F (GCN20), member 3
chr22_+_37407925 0.243 TOMM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
chr1_-_33275057 0.243 NM_001625
AK2
adenylate kinase 2
chr10_-_131799051 0.242 LOC387723
hypothetical LOC387723
chr19_+_49023283 0.242 NM_181845
ZNF283
zinc finger protein 283
chr19_+_42553895 0.241 NM_032453
ZNF527
zinc finger protein 527
chr2_-_63669265 0.240 NM_015910
WDPCP
WD repeat containing planar cell polarity effector
chr14_-_81069951 0.230 NM_005065
SEL1L
sel-1 suppressor of lin-12-like (C. elegans)
chr3_+_185386664 0.228 ABCF3
ATP-binding cassette, sub-family F (GCN20), member 3
chr22_+_37407899 0.223 NM_020243
TOMM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
chr3_+_14141633 0.218 TMEM43
transmembrane protein 43
chr17_-_18526296 0.218 NM_001145045
ZNF286B
zinc finger protein 286B
chr21_-_35174742 0.215 RUNX1
runt-related transcription factor 1
chr2_-_63669022 0.213 WDPCP
WD repeat containing planar cell polarity effector
chr16_+_65761905 0.209 NM_001185058
NOL3
nucleolar protein 3 (apoptosis repressor with CARD domain)
chr20_-_42713778 0.208 NM_000022
ADA
adenosine deaminase
chr4_+_157044296 0.205 NM_005651
TDO2
tryptophan 2,3-dioxygenase
chr8_-_56848423 0.203 NM_152417
TMEM68
transmembrane protein 68
chr18_+_41938295 0.195 NM_138443
HAUS1
HAUS augmin-like complex, subunit 1
chr6_+_84626083 0.194 NM_016230
CYB5R4
cytochrome b5 reductase 4
chr9_+_15412875 0.192 SNAPC3
small nuclear RNA activating complex, polypeptide 3, 50kDa
chr14_-_44500871 0.191 NM_017658
KLHL28
kelch-like 28 (Drosophila)
chr17_+_15543615 0.187 NM_001130842
NM_020652
ZNF286A

zinc finger protein 286A

chr2_+_165858586 0.187 NM_021007
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr2_-_63669085 0.186 WDPCP
WD repeat containing planar cell polarity effector
chr11_-_133628348 0.186 NM_001037304
NM_001037305
NM_014174
NM_199297
NM_199298
THYN1




thymocyte nuclear protein 1




chr8_-_109330116 0.184 NM_001568
EIF3E
eukaryotic translation initiation factor 3, subunit E
chr11_+_133628616 0.184 NM_014384
ACAD8
acyl-CoA dehydrogenase family, member 8
chr5_+_57914658 0.183 NM_138453
RAB3C
RAB3C, member RAS oncogene family
chr1_+_151897768 0.183 NM_012437
SNAPIN
SNAP-associated protein
chr19_+_62703136 0.182 ZNF773
zinc finger protein 773
chr14_-_76993641 0.181 NM_001193314
NM_001193315
NM_001193316
NM_001193317
NM_022067
VIPAR




VPS33B interacting protein, apical-basolateral polarity regulator




chrX_-_48818585 0.179 NM_007213
PRAF2
PRA1 domain family, member 2
chr2_-_218843109 0.179 NM_001087
AAMP
angio-associated, migratory cell protein
chr9_+_135994734 0.179 NM_052821
WDR5
WD repeat domain 5
chr20_-_25625173 0.177 NM_015655
ZNF337
zinc finger protein 337
chr8_-_109330101 0.176 EIF3E
eukaryotic translation initiation factor 3, subunit E
chr2_-_230792844 0.176 NM_004509
NM_004510
NM_080424
SP110


SP110 nuclear body protein


chr3_-_185025989 0.175 NM_024871
MAP6D1
MAP6 domain containing 1
chr9_+_15412862 0.175 SNAPC3
small nuclear RNA activating complex, polypeptide 3, 50kDa
chr6_+_84626146 0.175 CYB5R4
cytochrome b5 reductase 4
chr12_-_51153788 0.171 NM_173086
KRT6C
keratin 6C
chr15_-_72540484 0.169 UBL7
ubiquitin-like 7 (bone marrow stromal cell-derived)
chr6_+_84626113 0.169 CYB5R4
cytochrome b5 reductase 4
chr20_-_42713663 0.168 ADA
adenosine deaminase
chr17_-_3740785 0.167 NM_172206
CAMKK1
calcium/calmodulin-dependent protein kinase kinase 1, alpha
chr15_+_72540655 0.162 LOC440288
similar to FLJ16518 protein
chr9_-_129226312 0.162


chr19_-_49097774 0.159 LOC100505715
hypothetical LOC100505715
chr7_-_87774130 0.155 NM_024636
STEAP4
STEAP family member 4
chr1_-_109420091 0.155 NM_005645
TAF13
TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
chr19_+_62836322 0.152 NM_006385
NM_198855
ZNF211

zinc finger protein 211

chr12_+_119224506 0.151 NM_012240
SIRT4
sirtuin 4
chr3_+_125586241 0.150 KALRN
kalirin, RhoGEF kinase
chr19_+_49147219 0.149 NM_013359
ZNF221
zinc finger protein 221
chr19_-_61874934 0.149 ZNF835
zinc finger protein 835
chrX_+_105298953 0.147 NM_001171020
NM_152423
MUM1L1

melanoma associated antigen (mutated) 1-like 1

chrX_+_46935035 0.146 NM_153280
UBA1
ubiquitin-like modifier activating enzyme 1
chr18_-_41938196 0.145 NM_001001937
ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr13_+_24844084 0.143 NM_016529
ATP8A2
ATPase, aminophospholipid transporter, class I, type 8A, member 2
chr19_-_41672176 0.142 NM_032838
NM_001145343
NM_001145344
NM_001145345
ZNF566



zinc finger protein 566



chr19_+_44082410 0.141 NM_001001716
NM_002503
NFKBIB

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta

chr13_-_32822759 0.140 STARD13
StAR-related lipid transfer (START) domain containing 13
chr14_-_90780604 0.140 NM_001177676
GPR68
G protein-coupled receptor 68
chr1_-_233734088 0.138 B3GALNT2
beta-1,3-N-acetylgalactosaminyltransferase 2
chr3_+_14141583 0.136 TMEM43
transmembrane protein 43

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.04 1.08e-06 GO:0006355 regulation of transcription, DNA-dependent
1.97 5.84e-06 GO:0051252 regulation of RNA metabolic process
1.92 8.51e-06 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.86 2.07e-05 GO:0010468 regulation of gene expression
1.87 2.71e-05 GO:0010556 regulation of macromolecule biosynthetic process
1.80 6.34e-05 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.75 2.31e-04 GO:0051171 regulation of nitrogen compound metabolic process
1.74 5.76e-04 GO:0031326 regulation of cellular biosynthetic process
1.63 6.74e-04 GO:0060255 regulation of macromolecule metabolic process
1.72 9.00e-04 GO:0009889 regulation of biosynthetic process
1.58 1.91e-03 GO:0031323 regulation of cellular metabolic process
1.58 1.94e-03 GO:0080090 regulation of primary metabolic process
1.52 4.11e-03 GO:0019222 regulation of metabolic process
1.29 9.60e-03 GO:0065007 biological regulation
1.30 3.83e-02 GO:0050794 regulation of cellular process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.36 9.99e-11 GO:0043229 intracellular organelle
1.36 1.27e-10 GO:0043226 organelle
1.37 8.86e-09 GO:0043231 intracellular membrane-bounded organelle
1.37 1.00e-08 GO:0043227 membrane-bounded organelle
1.23 1.26e-06 GO:0044424 intracellular part
1.50 1.29e-06 GO:0005634 nucleus
1.22 4.12e-06 GO:0005622 intracellular
1.08 4.05e-02 GO:0044464 cell part
1.08 4.09e-02 GO:0005623 cell

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.05 1.32e-08 GO:0003677 DNA binding
2.00 8.63e-08 GO:0046914 transition metal ion binding
2.06 2.47e-07 GO:0008270 zinc ion binding
1.63 8.42e-05 GO:0003676 nucleic acid binding
1.54 2.53e-04 GO:0046872 metal ion binding
1.52 4.36e-04 GO:0043169 cation binding
1.52 4.91e-04 GO:0043167 ion binding